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. 2021 Jul 6;12:4015. doi: 10.1038/s41467-021-24265-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The left-hand (green) panel shows the distribution of the 4420 identified studies across study types. We created the (Pharmacological) RCT label following the procedure outlined in Methods section, the other classifications are taken from ClinicalTrials.gov. The right-hand panel (blue) shows the distribution of studies across the various mutually exclusive sex/gender groups we defined (see Methods section). In the ‘Some S/G mention’ set there is a hierarchy. The most extensive consideration was sex/gender as an analytical variable and after that sex/gender matching/representation, followed by explicit statements of intent to record or report participant sex/gender. Finally, the ‘Recruitment Only’ contains those studies whose only sex/gender mention was in a recruiting context. We allocated the studies to one of the categories based on the highest category of S/G consideration. For instance, if they reported attention to S/G in analysis and recruiting, we only counted them in analysis.