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. 2021 Jul 6;12:4147. doi: 10.1038/s41467-021-24380-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Pathways enriched in the list of genes co-occupied by ERG/EZH2 (GS_ERG/EZH2, n = 1656 genes) using enrich tool. b Functional analysis of the GS_ERG/EZH2 set using enrichDGN tool. c, d Heat map (c) and principal component analysis (d) using the GS_ERG/EZH2 set applied to primary prostate tumors (PRIMARY) and castration-resistant prostate cancers (CRPC) with known ERG and EZH2 status in the Michigan dataset. Color bars indicate ERG and EZH2 expression status. e GSEA using the GS_ERG/EZH2 set comparing ERG fusion positive and negative prostate tumors in the Sboner dataset. f Heat map with the top deregulated ERG/EZH2 gene signature (GS_ERG/EZH2_50) applied to the TCGA dataset. Color bars indicate ERG fusion and PTEN status.