Figure 1.

Cardiomyocyte cell number and size in wild type (wt) and Lmna^−/− mice. Both the cell number and size of cardiomyocytes were significantly reduced in Lmna^−/− mice (3 weeks old). (A) Total counts of cardiomyocytes in 10 tissue layers of the heart (n = 5 in each group). (B) Cross-section area of cardiomyocytes measured in a tissue section (n = 5 in each group). (C,D) Tissue sections stained with wheat germ agglutinin in wt (C) and Lmna^−/− (D) mice. The open circle represents wt, and the solid circle represents Lmna^−/− mice. The significance of differences between two groups was determined using the Student's 2 tailed T-test. Scale bar: 1 mm in lower magnification and 50 μm in higher magnification in inset.