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. 2021 Jun 23;8:639148. doi: 10.3389/fcvm.2021.639148

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Copyright © 2021 Onoue, Wakimoto, Jiang, Parfenov, DePalma, Conner, Gorham, McKean, Seidman, Seidman and Saito.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EdU incorporation and the percentage of EdU positive myocyte nuclei after apical resection. (A) Representative immunostaining for EdU in cardiac tissue sections of wt, Lmna^+/−, and Lmna^−/−. The top panel shows EdU staining, and the bottom panel shows merged figures of immunostaining for EdU (red), WGA, and troponin I (green) and DAPI (blue). Yellow arrows indicate EdU positive nucleus only in cardiomyocytes. Scale bar: 10 μm. (B) Percentage of EdU incorporated myocyte nuclei (n = 7 to 11 in each group). A circle indicates data from mice with the sham operation, square with apical resection. Dots represent individual mouse data. The significance of differences between 3 groups was determined with 1-way ANOVA. Post-hoc pairwise comparisons were performed with Tukey–Kramer test.