Table 2.
Top biological functions related to Lmna mutant mice in RNA-seq analysis.
| Lmna−/−/wt in 5 weeks | Lmna+/−/wt in 2 years | ||||
|---|---|---|---|---|---|
| Biological function | Number of genes/total genes in the category | P-value | Biological function | Number of genes/total genes in the category | P-value |
| Proliferation of cells | 686/5,802 | 1.48E-33 | Cell movement | 429/3,105 | 8.54E-48 |
| Cell death | 652/5,975 | 3.7E-31 | Migration of cells | 394/2,784 | 2.24E-46 |
| Apoptosis | 550/4,663 | 4.16E-31 | Proliferation of cells | 620/5,802 | 1.54E-38 |
| Necrosis | 508/4,635 | 6.94E-27 | Leukocyte migration | 218/1,449 | 1.77E-32 |
| Migration of cells | 382/2,784 | 9.68E-26 | Organization of cytoskeleton | 269/1,685 | 3.35E-32 |
| Cell movement | 413/3,105 | 6.20E-25 | Development of blood vessel | 196/1,176 | 2.17E-30 |
| Leukocyte migration | 199/1,449 | 1.50E-17 | Apoptosis | 486/4,663 | 5.71E-30 |
| Development of blood vessel | 185/1,176 | 2.42E-17 | Organization of cytoplasm | 278/1,816 | 1.77E-29 |
| Vascular disease | 178/1,280 | 3.92E-17 | Cell death | 569/5,975 | 1.88E-28 |
| Development of cardiovascular system | 225/1,460 | 5.38E-17 | Necrosis | 460/4,635 | 2.48E-28 |
Right-tailed Fisher's exact test.