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. 2021 Jun 23;11:647175. doi: 10.3389/fonc.2021.647175

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Copyright © 2021 Yu, Chan, Lin, Chiou, Lin, Chen, Lee, Chi, Chen, Huang, Chew, Hsu, Yang and Hung

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IRAK2 overexpression decreased OML1-R-generated in vivo tumor growth and enhanced radiosensitivity in the mice xenograft model. (A) In the mice xenograft model, IRAK2-overexpressed OML1-R-generated tumors had a relatively lower tumor growth rate than that of control OML1-R-generated tumors (P < 0.001). (B) Schema of cell injection and radiation treatments (upper panel). Since the 40th day after cancer cell injection, control and IRAK2-overexpressed mice were treated with RT per 4 days (i.e., a fraction size of 5 Gy by ten fractions to an accumulative dose of 50 Gy). The IRAK2-overexpressed mice had a smaller tumor volume than that of control mice at the time of radiotherapy (P = 0.0310; lower panel). (C) The expression of IRAK2, cleaved caspase-8, and cleaved caspase-3 in tumor tissues from control and IRAK2-overexpressed mice after radiotherapy were detected by immunohistochemical staining. (D) Immunoblotting analysis of the indicated proteins in lung tissues from control and IRAK2-overexpressed mice after irradiation. Densitometry-derived values (bottom) were normalized with the control set as 1. β-actin served as the loading control for normalization. Data were presented as mean ± SD. ‘***’ represented P < 0.001. All experiments were performed in triplicate.