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. 2021 Jun 23;11:647175. doi: 10.3389/fonc.2021.647175

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Copyright © 2021 Yu, Chan, Lin, Chiou, Lin, Chen, Lee, Chi, Chen, Huang, Chew, Hsu, Yang and Hung

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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After postoperative radiotherapy, OSCC patients with higher IRAK2 expressions showed better local recurrence-free survival (LRFS) than those with lower IRAK2 expressions. (A) Representative micrographs demonstrated the immunohistochemical (IHC) scores of IRAK2 expression in oral squamous cell carcinoma. (magnification, x200). (B) Kaplan-Meier survival curves represented that patients with higher IRAK2 expressions (i.e., >110) seemly demonstrated better 5-year LRFS than that of patients with lower expressions (i.e., 87.4% vs. 60.0%; P = 0.055, a statistical trend). (C) Cox proportional hazard regression confirmed this observation (univariate HR 0.25; 95% CI, 0.054 - 1.166; P = 0.055, a statistical trend). (D) Remarkably, after multivariable analysis, the two groups showed a statistically significant difference in terms of post-irradiation LRFS (multivariate HR 0.11; 95% CI, 0.016 - 0.760; P = 0.025). (E) Forest plot of multivariate analysis, depending on the Panel (D) Note that seven factors were used for multivariate analysis of LRFS (Panel C): age, gender, pathological stage, RT dose, chemotherapy, the status of surgical margin, and the expression level of IRAK2.