Table 1.
Patient characteristics of 41 oral cancer patients according to the expression level of IRAK2.
| IRAK2 | ||||||
|---|---|---|---|---|---|---|
| Low expression (n = 24) | High expression (n = 17) | P value | ||||
| Age (years) | (mean ± SD) | 51.3 ± 11.4 | 52.7 ± 10.1 | 0.70 | ||
| RT dose (cGy) | (mean ± SD) | 6338.3 ± 1378.4 | 6559.4 ± 1284.8 | 0.61 | ||
| Gender | Male | 23 | (96%) | 16 | (94%) | 0.80 |
| Female | 1 | (4%) | 1 | (6%) | ||
| Clinical stage | I | 8 | (33%) | 4 | (24%) | 0.88 |
| II | 11 | (46%) | 9 | (53%) | ||
| III | 2 | (8%) | 1 | (6%) | ||
| IVA/B | 3 | (13%) | 3 | (18%) | ||
| Pathologic stage | I | 15 | (63%) | 7 | (41%) | 0.18 |
| II | 9 | (38%) | 10 | (59%) | ||
| Surgical margin | <1 mm | 6 | (25%) | 1 | (5.9%) | 0.21 |
| ≧1~ ≦5 mm | 18 | (75%) | 16 | (94.1%) | ||
| Lymphovascular space invasion | No | 23 | (95.8%) | 14 | (82.4%) | 0.29 |
| Yes | 1 | (4.2%) | 3 | (17.6%) | ||
| Perineural invasion | No | 22 | (91.7%) | 13 | (76.5%) | 0.18 |
| Yes | 2 | (8.3%) | 4 | (23.5%) | ||
| Chemotherapy | No | 17 | (71%) | 10 | (59%) | 0.42 |
| Yes | 7 | (29%) | 7 | (41%) | ||
SD, standard deviation; RT, radiotherapy.
According to the principle of surgical oncology and our treatment policy, re-resection was the first treatment of choice for patients who had close-margin (i.e., ≦5 mm) pathology stage I-II OSCC. However, for those patients who had anatomic difficulty on re-resection and who had refusal of re-operation, salvage therapy of radiotherapy with or without chemotherapy was the alternative treatment choice, as that indicated for the above 41 patients.