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. 2021 Jul 6;11:13952. doi: 10.1038/s41598-021-93340-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan-Meyer survival analysis according pT3a substage and the combination of pT3a substage and circumferential margin (CM) status. (A) The biochemical recurrence (BCR)-free survival was significantly different among pT3a subgroups (P < 0.001). (B) No significant differences were identified in OS (P = 0.145). (C) After the combination of pT3a substage and CM status, significant differences were identified among 3 subgroups (P < 0.001). (D) pT3a2/3 + subgroup showed longer OS than other subgroups (P = 0.001).