Table 2.
Cox regression analysis of EPE parameters to affect pT3a prostate cancer patients’ survival.
| Category | Variable | Unadjusted | Adjusted* | C-index | ||
|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |||
| BCR | Radial distance ≤ 0.75 mm | 1 | 1 | |||
| Radial distance > 0.75 mm | 1.219 (1.166–1.274) | < 0.001 | 2.228 (1.175–4.226) | 0.014 | 0.648 | |
| 2D square area ≤ 2.00 mm2 | 1 | 1 | ||||
| 2D square area > 2.00 mm2 | 1.004 (1.002–1.005) | < 0.001 | 1.525 (0.937–2.484) | 0.090 | 0.641 | |
| Number of EPEs ≤ 1 | 1 | 1 | ||||
| Number of EPEs > 1 | 1.534 (1.377–1.710) | < 0.001 | 1.355 (0.933–1.968) | 0.110 | 0.612 | |
| Overall survival | Radial distance ≤ 0.75 mm | 1 | 1 | |||
| Radial distance > 0.75 mm | 1.146 (0.967–1.359) | 0.117 | 0.909 (0.333–2.484) | 0.853 | 0.602 | |
| 2D square area ≤ 2.00 mm2 | 1 | 1 | ||||
| 2D square area > 2.00 mm2 | 1.003 (0.998–1.007) | 0.288 | 0.865 (0.349–2.145) | 0.754 | 0.607 | |
| Number of EPEs ≤ 1 | 1 | 1 | ||||
| Number of EPEs > 1 | 1.345 (0.960–1.884) | 0.085 | 1.451 (0.608–3.462) | 0.402 | 0.604 | |
| Cancer specific survival | Radial distance ≤ 0.75 mm | 1 | 1 | |||
| Radial distance > 0.75 mm | 1.258 (1.044–1.514) | 0.016 | 2.880 (0.368–22.156) | 0.313 | 0.724 | |
| 2D square area ≤ 2.00 mm2 | 1 | 1 | ||||
| 2D square area > 2.00 mm2 | 1.004 (0.998–1.010) | 0.191 | 1.975 (0.426–9.153) | 0.385 | 0.694 | |
| Number of EPEs ≤ 1 | 1 | 1 | ||||
| Number of EPEs > 1 | 1.393 (0.886–2.191) | 0.152 | 2.463 (0.744–8.152) | 0.140 | 0.665 | |
*Adjusted for age, initial PSA level, prostate grade group, tumor volume, perineural invasion, lymphovascular invasion, apex margin extension, basal margin extension, circumferential margin extension, vas deferens margin extension, lymph node metastasis.