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. 2021 Jul 6;12:4156. doi: 10.1038/s41467-021-24068-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Behavioural protocol. CS: conditioned stimuli. b Behavioural data. B6 mice: n = 4; extinction memory retrieval, no CS: 21.4 ± 16.2%, CS: 32.5 ± 6.4%, fear renewal, no CS: 34.8 ± 1.2%, CS: 73.0 ± 7.3%, blocks of 4 CSs. One-way repeated-measures ANOVA F_(3,9) = 8.5, p = 0.005 followed by post hoc Bonferroni t-test vs. CS block during extinction memory, p = 0.015. Bar plots are expressed as means ± SEM. Circles are freezing values of individual mice. c Raster plots and corresponding spike waveforms of a representative CEm unit (top). Normalized and averaged population peri-stimulus time histograms (bottom). CEm neurons: n = 4 units from 1 mouse; z-score, extinction memory retrieval: −0.79 ± 1.59, fear renewal: 3.08 ± 1.06, blocks of 4 CSs. Paired student t-test, two-sided, p = 0.039. d Raster plots and corresponding spike waveforms of a representative CEloff unit (top). Normalized and averaged population peri-stimulus time histograms (bottom). CEloff neurons: n = 7 units from 2 mice; z-score, extinction memory retrieval: −0.04 ± 0.61, fear renewal: −0.94 ± 0.40, blocks of 4 CSs. Paired student t-test, two-sided, p = 0.041. e Raster plots and corresponding spike waveforms of a representative CElon unit (top). Normalized and averaged population peri-stimulus time histograms (bottom). CElon neurons: n = 10 units from 2 mice; z-score, extinction memory: 1.28 ± 0.41, fear renewal: 2.13 ± 0.37, blocks of 4 CSs. Paired student t-test, two-sided, p = 0.034. All individual neurons of each CEA population had significant z-score values upon CS presentation (4 CSs during fear renewal). Source data are provided as a Source data file.