Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 6;11:13871. doi: 10.1038/s41598-021-93346-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The co-regulation of pleiotropic genes associated with T1D and T2D is non-random. (a) A plot showing the number of unique and shared SNPs (imputed and genotyped) associated with the development of T1D and T2D identified from genome-wide association studies. (b) A normal distribution plot for randomly sampled SNPs (bootstrapping; n = 10,000) validates the significance of overlaps seen in (a). (c) The numbers of unique and shared genes modulated by T1D and T2D regulatory SNPs. (d) A normal distribution plot for randomly sampled genes (bootstrapping; n = 10,000) validates the significance of overlaps seen in (c). eGene—a gene whose transcript levels is associated with an eQTL, eQTL—SNPs associated with transcript levels of genes. Red lines in (b) and (d) illustrates the fitted normal distribution lines.