Table 3.
Robust IPW-weighted generalized regression analyses on PC1 for ETOPFA-adjusted congenital anomaly data.
| Parameter | Estimate (C.I.) | P-Value |
|---|---|---|
| ETOPFA data | ||
| Drugs—additive model | ||
| svyglm(PC1_ETOPFA_anomalies ~ cigarettes + AUD + mrjmon + Analgesics + cocaine + MHY) | ||
| Cannabis | 1.56 (0.51, 2.6) | 0.0071 |
| Cigarettes | − 13.19 (− 17.62, − 8.75) | 3.83E−06 |
| Drugs—interactive model | ||
| svyglm(PC1_ETOPFA_anomalies ~ cigarettes * AUD * mrjmon + Analgesics + cocaine + MHY) | ||
| AUD | 98.08 (58.27, 137.89) | 5.81E−05 |
| AUD: Cannabis | 21.02 (2.59, 39.44) | 0.0345 |
| Cigarettes: AUD | − 229.76 (− 329.02, − 130.5) | 0.0001 |
| Cannabinoids—additive model | ||
| svyglm(PC1_ETOPFA_anomalies ~ cigarettes + AUD + THCRt + CBGRt + CBCRt + analgesics + cocaine) | ||
| CBG | 2.94 (1.39, 4.48) | 0.0010 |
| CBC | − 1.53 (− 2.67, − 0.39) | 0.0146 |
| Cigarettes | − 13 (− 17.52, − 8.48) | 7.33E−06 |
| Cannabinoids—interactive model | ||
| svyglm(PC1_ETOPFA_anomalies ~ cigarettes * aUD * THCRt * CBGRt * CBCRt + analgesics + cocaine) | ||
| Cigarettes: CBG | 4.53 (2.67, 6.39) | 6.70E−05 |
| CBG | 3.49 (0.44, 6.53) | 0.0338 |
| Cigarettes: THC: CBC | 3.78 (0.23, 7.34) | 0.0473 |
| Full additive model | ||
| svyglm(PC1_ETOPFA_anomalies ~ cigarettes + AUD + PC1_Cannabinoids + analgesics + cocaine + income + 6_races) | ||
| PC1_Cannabinoid | 0.64 (0.22, 1.06) | 0.0063 |
| Cigarettes | − 12.33 (− 16.59, − 8.07) | 5.73E−06 |
| Full interactive model | ||
| svyglm(PC1_ETOPFA_anomalies ~ cigarettes * AUD * PC1_cannabinoids + analgesics + cocaine + income + 6_races) | ||
| PC1_Cannabinoid | 0.64 (0.22, 1.06) | 0.0063 |
| Cigarettes | − 12.33 (− 16.59, − 8.07) | 5.73E−06 |
| Cannabinoids full additive model | ||
| svyglm(PC1_ETOPFA_anomalies ~ cigarettes + THC + CBG + CBC + AUD + Analgesics + cocaine + income + 6_races) | ||
| CBG | 3.94 (2.62, 5.25) | 6.46E−06 |
| AIAN | 19.58 (12.65, 26.52) | 1.46E−05 |
| Cocaine | 94.7 (12.92, 176.47) | 0.03337 |
| AUD | − 26.81 (− 45.85, − 7.78) | 0.01141 |
| CBC | − 2.8 (− 4.48, − 1.11) | 0.00366 |
| Cigarettes | − 11.53 (− 15.82, − 7.24) | 2.79E−05 |
| Cannabinoids full interactive model | ||
| svyglm(PC1_ETOPFA_anomalies ~ cigarettes * THC * CBG * CBC + AUD + Analgesics + cocaine + income + 6_races) | ||
| AIAN | 11.36 (8.14, 14.58) | 6.01E−07 |
| CBG | 3.8 (1.74, 5.86) | 0.0015 |
| Cocaine | 78.22 (7.94, 148.49) | 0.0401 |
| Cigarettes: CBC | − 14.08 (− 24.26, − 3.9) | 0.0128 |
| Cigarettes | − 73.02 (− 115.67, − 30.38) | 0.0029 |
| Asian | − 19.81 (− 29.84, − 9.77) | 0.0008 |
Final robust generalized linear regression models for ETOPFACAR Dataset.