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. 2021 Jul 6;11:13892. doi: 10.1038/s41598-021-93411-5

Table 5.

E-values of instrumental variable regression models.

Parameter Estimate (C.I.) E-Value
RAW RATES
Drugs—additive model
 Cannabis 1.17 (0.3, 2.04) 5.02, 1.93
Drugs—interactive model
 Cigarettes: Cannabis 19.28 (13.34, 25.21) 2.09E + 08, 7.18E + 04
 AUD: Cannabis 69.54 (42.68, 96.4) 1.71E + 29, 1.20E + 18
Cannabinoids—additive model
 CBG 0.95 (0.3, 1.6) 4.04, 1.94
Cannabinoids—interactive model
 Cigarettes: CBG 3.67 (2.77, 4.56) 48.91, 22.14
Full additive model
 PC1-Cannabinoids 0.6 (0.33, 0.87) 3.03, 2.12
Full interactive model
 PC1-Cannabinoids 4.37 (2.97, 5.77) 213.43, 47.55
ETOPFA DATA
Drugs—additive model
 Cannabis 1.29 (0.4, 2.17) 5.51, 2.17
Drugs—interactive model
 Cigarettes: AUD: Cannabis 73.95 (48.33, 99.57) 2.13E + 26, 2.14E + 17
Cannabinoids—additive model
 CBG 3.14 (1.74, 4.54) 37.77, 9.79
Cannabinoids—interactive model
 Cigarettes: CBC 2.31 (1.5, 3.11) 17.25, 7.75
 CBG 7.38 (4.18, 10.57) 2.16E + 03, 105.18
 CBG: CBC 0.98 (0.49, 1.47) 4.51, 2.57
Full additive model
 PC1-Cannabinoids 0.68 (0.39, 0.97) 3.15, 2.23
Full interactive model
 PC1-Cannabinoids 5.4 (3.79, 7) 595.814, 109.21
Cannabinoid Full Additive Model
 CBG 4.21 (2.91, 5.5) 176.69, 44.16
CANCER DATA
Drugs—additive model
 Cannabis 0.45 (0.2, 0.69) 2.83, 1.87
Drugs—interactive model
 Cigarettes: Cannabis 14.84 (10.88, 18.79) 2.82E + 07, 3.53E + 05
Cannabinoids—additive model
 THC 1.98 (1.61, 2.36) 18.58, 12.01
Cannabinoids—interactive model
 CBC 12.78 (6.96, 18.59) 1.53E + 07, 1.14E + 04
 THC: CBC 3.02 (1.33, 4.71) 84.47, 9.91
 THC: CBG: CBC 0.6 (0.17, 1.04) 3.63, 1.76
 CBG 7.27 (0.46, 14.09) 1.66E + 04, 2.99
 CBG: CBC 1.79 (0.1, 3.49) 18.01, 1.53
Full additive model
 PC1-Cannabinoid 0.35 (0.29, 0.41) 2.51, 2.25
Full interactive model
 Cigarettes: PC1-Cannabinoid 6.63 (4.8, 8.46) 1.45E + 04, 1.25E + 03
Full additive model with cannabinoids
 THC 1.48 (1.19, 1.77) 14.18, 9.43
Full interactive model with cannabinoids
 CBG 10.6 (4.39, 16.81) 7.52E + 06, 1.08E + 03
 THC: CBG: CBC 3.81 (1.54, 6.08) 4159.71, 17.54
 CBG: CBC 2.47 (0.93, 4) 67.03, 7.00
 THC: CBG 16.09 (5.82, 26.36) 1.89E + 10, 9.37E + 03
 CBC 7.52 (2.44, 12.59) 9.16E + 05, 65.62
 THC 46.13 (11.12, 81.15) 8.05E + 28, 1.73E + 07
 THC: CBC 11.15 (0.87, 21.42) 1.63E + 07, 6.57

E-Values from instrumental variable regression models.