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. 2021 Jul 6;11:13923. doi: 10.1038/s41598-021-93224-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Infusion of IB-hASCs suppresses body-weight gain and improves glucose tolerance in DIO mice. (a) Body-weight progression and (b) food intake of high-fat diet-treated mice infused with W-hASCs, IB-hASCs or saline (n = 6). (c) Percentage of body fat content. (d) Energy expenditure. (e) Glucose tolerance test (n = 6) and area under the curve (AUC) analysis. (f) Insulin tolerance test (n = 5–6) and AUC analysis. (h) Fed and fasted plasma glucose levels. Results are expressed as mean ± s.e.m. *P < 0.05, **P < 0.01 (two-way ANOVA; one-way ANOVA).