FIGURE 3.

Bone histomorphometric findings in two subjects with a heterozygous mutation p.G218R in ARHGAP25. Toluidine blue staining of biopsies from (A,C,E) 69‐year‐old female (II‐2, index) and (B,D,F) 64‐year‐old female (II‐4, sister) showing loss of interconnection among trabecular plates, trabecular thinning and reduction in trabecular number, and reduction in number of resorption sites. Biopsies from both (G) II‐2 and (H) II‐4 also had reduced tetracycline uptake and only a few visible double labels.