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. 2021 Jun 23;11:646338. doi: 10.3389/fonc.2021.646338

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Copyright © 2021 Niu, Liu, Xu, Peng, Yu, Huang, Wu, Cui, Huang, Ma, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Somatic mutation landscape of ccRCC with and without VTT. (A) Mutation landscape of the NP (n = 25), VP (n = 25), and V (n = 23) samples. The vertical histogram shows the number of different mutational types in each sample. The heat map shows the distribution of top genes across samples. The horizontal histogram shows the number of different mutational types in each gene. (B) The tumor mutation burden of the V, VP, and NP groups. (C) The frequency of mutations in driver genes of ccRCC in the three groups (V, VP, and NP) and in data obtained from TCGA. TCGA, The Cancer Genome Atlas; VTT, venous tumor thrombus; ccRCC, clear cell renal cell carcinoma; V, VTT; VP, matched primary tumor; NP, normal primary tumors without VTT.