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. 2021 Jun 23;11:646338. doi: 10.3389/fonc.2021.646338

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Copyright © 2021 Niu, Liu, Xu, Peng, Yu, Huang, Wu, Cui, Huang, Ma, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mutational signature profile and DNA damage repair pathway analysis. (A) The distribution of DDR somatic mutations in each group (V, VP, and NP). The prevalence of HRD score (B) and microhomology deletions (C). (D) Mutational signature in each group (NP, V, and VP). AC, Alexandrov COSMIC; DS, damage sensor; HR, homologous recombination repair; DDR, DNA damage repair; FA, Fanconi anemia; MMR, mismatch repair; NER, nucleotide excision repair; BER, base excision repair; VTT, venous tumor thrombus; V, VTT; VP, matched primary tumor; NP, normal primary tumors without VTT; HRD, homology recombination deficiency.