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. 2021 Jun 23;11:646338. doi: 10.3389/fonc.2021.646338

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Copyright © 2021 Niu, Liu, Xu, Peng, Yu, Huang, Wu, Cui, Huang, Ma, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CNVs of tumors were plotted by chromosomal location (vertical axis) of the entire dataset in the V (A), VP (B), and NP groups (C). (D) Differences in the copy number deletions and duplications in the three groups. (E) The counts of deletion of chromosome 3p (Chr3p Del), duplication of chromosome 5q (Chr5q Dup), deletions of chromosome 9 (Chr9 Del) and chromosome 14 in the three groups. *p < 0.05; **p < 0.01. CNV, copy number variation; VTT, venous tumor thrombus; V, VTT; VP, VTT matched primary tumor; NP, normal primary tumors without VTT.