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. 2021 Jun 23;11:646338. doi: 10.3389/fonc.2021.646338

Figure 6.

Figure 6

Clinical features and tumor microenvironment of the ccRCC patients with deletions in chromosomes 9 and 14 based on the KIRC database. (A) Clinical features of the ccRCC patients in the KIRC database with or without deletions in chromosome 9 (left) or 14 (right). (B) Kaplan–Meier curves for OS of ccRCC patients in the KIRC database with or without chromosome 9 and/or 14 deletions. (C) Heat map of gene expression signatures in angiogenesis, immune and antigen presentation and myeloid inflammation of ccRCC patients in the KIRC database with or without chromosome 9 and/or 14 deletion. (D) Analysis of tumor-infiltrating immune cell types in ccRCC patients in the KIRC database with or without chromosome 9 and/or 14 deletion. (E) Analysis of tumor-infiltrating immune cell types in ccRCC patients in the KIRC database with or without deletions in chromosome 9. Immunostaining (F) and analysis (G) for CD4, CD8 and CD3 in the V, VP, and NP groups. (G) *p < 0.05; **p < 0.01; ***p < 0.001. ccRCC, clear cell renal cell carcinoma; KIRC, kidney renal clear cell carcinoma; OS, overall survival; V, VTT; VP, VTT matched primary tumor; NP, normal primary tumors without VTT.