Fig. 4.

Targeted delivery of doxorubicin mediated by anti-CD147 antibody modified PAR28-PEG-lipo. CD147-positive A375 cells were treated with doxorubicin (DXR)-encapsulated PAR28-PEG-lipo modified with isotype control IgG (Cont. Ab) or anti-CD147 antibody (Anti-CD147). After incubation for 6 h, intracellular DXR was observed by CLSM. (A) Typical CLSM images of intracellular DXR delivered by Cont. Ab (upper image)- and Anti-CD147 (lower image)- modified liposomes. Red signals indicate DXR. Scale bar: 50 μm. (B) the percent of DXR-positive cells. n = 5, ***P < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)