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. 2021 Jul 1;37(7):505–509. doi: 10.1089/aid.2020.0228

FIG. 1.

FIG. 1.

Re-emergence of naturally acquired coccidioidomycosis (CM) in an SIV virally-suppressed, immunologically intact PTM. (A) Time line of PTM indicating transient detection of natural CM, fluconazole treatment (Rx), and experimental SIVmac239M infection with subsequent cART. CM recrudescence led to clinically required euthanasia in June 2020. (B) IgG and IgM Coccidioides antibody titers measured by endpoint ELISA in blood plasma. (C) Plasma SIV VL measured by RT-qPCR (limit of detection is 30 copies/mL of plasma), and CD3+CD4+ cell counts measured via flow cytometry. (D) Clinically relevant CBC analytes following SIV infection; WBC, lymphocytes (Lymph), and monocytes (Mono) measured in whole blood by Beckman Coulter® AC*T™ 5 Diff Hematology Analyzer. (C–D) Shaded regions indicate period of cART. cART, combination antiretroviral therapy; CM, coccidioidomycosis; ELISA, enzyme-linked immunosorbent assay; PTM, pigtail macaque; RT-qPCR, real-time qualitative polymerase chain reaction; SIV, simian immunodeficiency virus; VL, viral load; WBC, white blood cell.