FIG 1.

CONSORT diagrams. (A) 7/8 stratum. (B) 8/8 stratum. ^aPatients were randomly assigned between March 1, 2013, and December 9, 2014. Following a protocol amendment, subjects in the 7/8 cohort were nonrandomly assigned to receive abatacept. The remaining 7/8 patients were randomly assigned between December 19, 2014, and November 30, 2016. ^bPatient determined to be ineligible because of disease progression prior to day 1. ^cPatient excluded because of confirmation of Li-Fraumeni Syndrome prior to day 1.