Table 2.
Patient demographic, clinical and laboratory data for validation cohort.
| Parameter | Obese controls | NAFL | NASH |
|---|---|---|---|
| Number | 11 | 100 | 94 |
| Age (years) | 48.10 ± 2.86 | 45.20 ± 1.27 | 48.96 ± 1.67 |
| Gender (M/F) | 4/6 | 26/66 | 34/56 |
| BMI (kg/m2) | 46.03 ± 1.87 | 44.60 ± 0.67 | 45.89 ± 0.73 |
| Hematology and biochemistry | |||
| AST (U/L) | 23.78 ± 5.93 | 20.71 ± 0.92 | 26.24 ± 1.49a |
| ALT (U/L) | 22.67 ± 3.43 | 25.68 ± 1.70 | 35.18 ± 2.21a |
| GGT (U/L) | 21.14 ± 3.52 | 37.20 ± 4.78 | 42.27 ± 4.45 |
| Glucose (mg/dl) | 108.30 ± 6.77 | 113.65 ± 3.44 | 120.22 ± 3.39 |
| Triglycerides (mg/ml) | 127.00 ± 32.44 | 142.22 ± 9.98 | 158.79 ± 8.43 |
| Total cholesterol (mg/ml) | 198.25 ± 4.91 | 195.75 ± 4.08 | 206.79 ± 5.41 |
| HDL-cholesterol (mg/ml) | 51.50 ± 4.84 | 48.58 ± 1.47 | 50.24 ± 1.45 |
| LDL-cholesterol (mmol/dl) | 131.30 ± 8.31 | 118.38± 3.65 | 125.69 ± 4.12 |
| Total bilirubin (mg/dl) | 0.54 ± 0.10 | 0.55 ± 0.09 | 0.48 ± 0.03 |
| Platelets (109/L) | 281.00 ± 33.57 | 267.78 ± 7.09 | 251.79 ± 6.22 |
| Hemoglobin (g/dl) | 12.40 ± 0.61 | 13.73 ± 0.13 | 13.75 ± 0.21 |
| Ferritin (ng/ml) | 166.87 ± 31.14 | 114.15 ± 15.91 | 134.34 ± 19.79 |
| Albumin (g/dl) | 3.96 ± 0.27 | 4.28 ± 0.05 | 4.28 ± 0.06 |
| INR | 1.01 ± 0.02 | 0.97 ± 0.01 | 0.98 ± 0.01 |
| Liver steatosis | |||
| MRI (fat fraction) | n/a | 0.15 ± 0.01 | 0.26 ± 0.01a |
| Hepatic TG content evaluated by Folch method (mg/g) | n/a | 57.49 ± 5.47 | 103.13 ± 6.42a |
| NAFLD-associated polymorphisms | |||
| PNPLA3 (CC/CG/GG) | 7/0/1 | 59/24/6 | 47/28/9 |
| TM6SF2 (CC/CT/TT) | 8/0/0 | 63/5/3 | 65/5/0 |
| MBOAT7 (GG/GA/AA) | 4/4/0 | 21/50/18 | 27/42/15 |
| Co-morbidities | |||
| Arterial hypertension (no/yes) | 6/4 | 46/45 | 31/59 |
| Diabetes (no/yes) | 5/5 | 66/26 | 55/34 |
| Dyslipidemia (no/yes) | 3/1 | 55/23 | 41/41a |
| Cholelithiasis (no/yes) | 3/1 | 52/23 | 60/19 |
Data are expressed as mean ± SEM. Information not available for non-obese controls.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; C, cytosine; F, female; G, guanine; GGT, γ-glutamyl transferase; HDL, high-density lipoprotein; INR, international normalized ratio; LDL, low-density lipoprotein; M, male; MRI, magnetic resonance imaging; n/a, not available; NAFL, nonalcoholic fatty liver; NASH, nonalcoholic steatohepatitis; T, thymine.
a
p < 0.05 vs. NAFL.