TABLE 1.

Summary of published articles on Stem Cell Therapy in Stroke.

#	Report/year	Route	Study design	Stem cell type	Dose	Timing	n	Phase	Stroke type	F-U	1° outcome indicator	Cells origin
1	Bang et al., 2005	IV	Randomized controlled	BMSCs	5 × 107	4 weeks	30	I/II	Subacute	12	mRS, BI	PIC
2	Lee et al., 2010	IV	Open-label, observer blinded, randomized	BMSCs	5 × 107	1–4 weeks	16		Acute	60	mRS, BI	PIC
3	Savitz et al., 2011	IV	Prospective open label	BMNCs	10 × 106	1–3 days	10	I	Acute/Subacute	12	BI, NIHSS, mRS.	PIC
4	Honmou et al., 2011	IV	N/A	ExoMSCs	0.6–1.6 × 108	36–133 days	12	I/II	Chronic	12	mRS, NIHSS,	PIC
5	Bhasin et al., 2011	IV	Nonrandomized	BMSC	50–60 × 106	3–12 months	12	I	Chronic	6	NIHSS, FM, mRS	PIC
6	Bhasin et al., 2012	IV	Non-randomized	BM-MNCs	50–60 × 106	3–24 months	12	I	Chronic	6	FMA, BI	PIC
7	Bhasin et al., 2013	IV	Non-randomized, unblinded, case control	BM-MSCs	50–60 × 106	3–24 months	20	I/II	Chronic	24	MRI, BI, FM,	PIC
8	Díez-Tejedor et al., 2014	IV	Prospective, randomized, double-blind, placebo	Allogenic MSCs from adipose tissue	1 × 106	2 weeks	20	IIa	Acute	24	mRS, NIHSS, MRI	Adipose tissue.
9	Prasad et al., 2014	IV	Multicentric, parallel group	BMNCs	280.75 × 106	7–30 days	60	II	Subacute	6	NIHSS, BI, mRS.	PIC
			controlled
10	Taguchi et al., 2015	IV	Non-randomized, open label	BMNC	2.5–3.4 × 108	7–10 days	12	I	Acute	6	NIHSS, mRS, BI	PIC
11	Bhasin et al., 2016	IV	Randomized, controlled	BMNC+MSCs	50–60 × 106	3–24 months	20	I	Chronic	6	FMA, BI	PIC
12	Hess et al., 2017	IV	Randomized, double-blind, placebo-controlled Multicentric	Multipotent adult progenitor cells	400–1,200 × 106	24–48 h	65	II	Acute	12	BI, mRS, NIHSS	Multipot ent adult progenito r cells
13	Laskowitz et al., 2018	IV	Open label	Umbilical cord	3.34 × 106	3–9 days	10	I	Acute	12	mRS	Allogeni c umbilical cord
14	Vahidy et al., 2019	IV	Single arm	BMNCs	Maximum dose: 10 × 106 + escalated doses: 8–9 × 106 + 5–8 × 106.	1–3 days	25	I	Acute	24	mRS, NIHSS	Autologo us bone marrow
15	Tsang et al., 2017	IV	Randomized, controlled, double-blind	BMSC	4.57 × 107	N/A	9	I/II	Chronic	14	GOSE BI	PIC
16	Levy et al., 2019	IV	Preliminary safety and efficacy	BMSCs	0.5–1.5 × 106	Mean 6 months	36	I/II	Chronic	12	BI, ECG, CT.	Allogeni c MSCs.
16	Lv et al., 2013	IV. + IT	N/A	Umbilical-MS Cs	100 × 106	7–30 days	60	I/II	Chronic	3–12	FMA	Umbilica l cord
17	Battistella et al., 2011	IA	Approximation study	BM-MNCs	1–5 × 108	1–180 days	6	I	Chronic	6	NIHSS, Doppler, MRI, mRS, BI	PIC
18	Friedrich et al., 2012	IA	Non-randomized, non-controlled	BM-MNCs	15 ml	Mean 3–9 days	20	I	Subacute	6	NIHSS, mRS, CT,	PIC
19	Moniche et al., 2012	IA	Single blind controlled	BM-MNCs	159 m. (3.3 × 106 CD34+)	Mean 5–9 days	10	I/II	Subacute	6	NIHSS, BI, mRS	PIC
20	Banerjee et al., 2014	IA	Prospective, non-randomized, open label	CD34+ stem/Progenitor	100 × 106	7 days	5	I	Acute	6	MRI, NIHSS, mRS	PIC
21	Savitz et al., 2019	IA	Randomized, prospective, controlled, multicentre, blinded	BM/ALD-401		1–90 days	30		Acute	24	mRS, BI, RMN, NIHSS	PIC
22	Suárez-Monteagudo et al., 2009	IC-S	N/A	BMSC	N/A	1–10 years	5		Chronic	12	NIHSS, MRI, SF-36	PIC
23	Kondziolka et al., 2000	IC-S	Open label, observer blinded	Neurons	6 × 106	6–72 months	18	I	Chronic	18	ESS, PET, BI SF-36, NIHSS	Cultured neurons
24	Kondziolka et al., 2005	IC-S	Open-label, observer blinded	Neurons	5–10 × 106	>6 months	14	II	Chronic	12	ESS, PET, BI SF-36, NIHSS	Cultured neurons
25	Chen et al., 2014	IC-S	Randomized single-blind	PBSCs	3–8 × 106	6.60 months	15	I	Chronic	12	NIHSS, mRS	PBSCs
26	Kalladka et al., 2016	IC-S	Open-label, single site	CTX-DP	2–20 × 106	6–60 months	13	I	Chronic		NIHSS, mRS, MRI, BI, Ashworth	Immortalized h. stem-cell
27	Zhang et al., 2019	IC-S	Cohort	NSI-566 1°adherent neural stem cells	A = 1.2 × 107 B = 2.4 × 107 C = 7.2 × 107	Mean 494 days	9	I	Chronic	24	CT, fMRI, PET, DTU	Cells derived from human fetal spinal cord
28	Steinberg et al., 2019	IC-S	Open label single arm	BMSC SB623	2.5–10 × 106	6–60 months	18	I/IIa	Chronic	24	NIHSS, mRS, ESS, FM	Allogeni c bone marrow derived.
29	Feng et al., 2014	IT	N/A	UC-MSCs	100 × 106	14–30 days	50		Subacute	3	NIHSS, FMA	Lianonin g blood center