Figure 5.

Proteins increased in abundance in Nab2^ex3and Nab2 oe brains are enriched for processes including RNA processing and neurodevelopment.A–C, the enriched terms from FlyEnrichr database for biological process resulting from the subset of proteins increased in abundance that are (A) unique to Nab2^ex3, (B) unique to Nab2 oe, and (C) shared between Nab2^ex3 and Nab2 oe. The bars shown correspond to the top ten c-scores (c-score = ln(adj p-val) ∗ z-score) in each dataset (adj. p-val < 0.05) (74, 75, 76). D, a chord plot showing how proteins are represented in multiple GO biological process terms enriched from the subset of proteins increased in abundance in both Nab2^ex3 and Nab2 oe relative to control. The selected terms are shown on the right of the plot and are color-coded according to the legend, with the chords extending to the left of the plot showing which proteins are represented in each term. The log₂ (Nab2^ex3/Cont) in Nab2^ex3 is represented by color change (white to red) next to each protein annotation. GO, gene ontology.