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. 2021 Jun 23;12:673509. doi: 10.3389/fmicb.2021.673509

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Copyright © 2021 Avula, Singh, Kumar and Syed.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic summary of the lipid transfer proteins as attractive therapeutic avenues against viruses. OSW1, ITZ (Itraconazole), POS (Posaconazole) binds to OSBP and inhibits its lipid shuttling activity at the ER-Golgi or ER-Viral replication membrane contact sites resulting in the disruption of viral replication sites. HPA-12 is a CERT inhibitor that inhibits ceramide trafficking from the ER to the site of sphingomyelin synthesis. PIK93 can inhibit both PI4KIIIα and PI4KIIIβ whereas AL9 inhibits PI4KIIIα thereby inhibiting PI4P production and recruitment of OSBP and CERT, which eventually affects non-vesicular lipid transport and viral replication sites integrity. U18666A binds to the luminal loop of NPC1 and blocks NPC1 mediated cholesterol flux from late endosomes/lysosomes thereby affecting viral entry and release into the cytosol (Created with BioRender.com).