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. 2021 Jun 23;12:673509. doi: 10.3389/fmicb.2021.673509

TABLE 1.

Antivirals targeting lipid transfer protein.

Virus LTP Target step Inhibitor References
HCV OSBP Replication Itraconazole
Posaconazole
OSW1
Sohda et al. (2001)
Sohda et al. (2001)
van Meer (1989)
HCV GLTP Replication Bicyclol Shim et al. (2016)
HCV CERT Secretion HPA-12 Yasuda et al. (2001),
Aizaki et al. (2008)
HCV NPC1L1 Entry Ezetimibe Sainz et al. (2012)
Enteroviruses OSBP Replication Itraconazole
TTP-8307
OSW1
Sohda et al. (2001)
Sun et al. (2015)
Albulescu et al. (2017)
DENV OSBP Replication Posaconazole
OSW1
Sierra et al. (2017)
Burgett et al. (2011)
EBOV NPC1 Entry U18666A 3.47
MBX2254
MBX2270
Wichit et al. (2017)
Côté et al. (2011)
Basu et al. (2015)
CHIKV NPC1 Entry Imipramine Wichit et al. (2017)