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. 2021 Jul 4;69:103464. doi: 10.1016/j.ebiom.2021.103464

Fig. 4.

Fig. 4

Characterization of T cell phenotype and HBcAg-specific T cell responses in cHBV patients received IFN-α treatment. (a and b) CD4+ and CD8+T cell phenotypes were compared between HBV patients received no therapy (NT, n = 24), NUC monotherapy (NUC, n = 48) and peg-IFN-α contained therapy (IFN, n = 25). Percentages are represented by the heat map as Z scores of log2 transformed. Each column represents a single patient and patients with undetected T cell markers did not show on the heatmap. (c) HBcAg-specific T cell responses were compared between HBV patients received no therapy (NT, n = 24), NUC monotherapy (NUC, n = 48) and peg-IFN-α contained therapy (IFN, n = 25). Data are presented as median and statistical analysis was performed by GraphPad Prism using Kruskal-Wallis test followed by Dunn's multiple comparisons test; *P < 0·05; **P < 0·01; ***P < 0·001; ****P < 0·0001; ns, not significant.