Figure 2.

Deficiency of caspase-11–attenuated MCD-induced hepatic steatosis in mice. Casp11^+/+ (WT) or Casp 11^–/– mice were treated with MCD for 8 weeks to induce NASH. Paraffin-embedded liver sections were stained with (A) hematoxylin and eosin, and (B) hepatic steatosis and (C) ballooning scores were calculated. (D) Serum ALT level, (E) serum AST level, and (F) liver triglycerides were detected. n = 5 for 2 control groups, n = 8 for 2 MCD groups. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001.