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Deficiency of caspase-11–attenuated MCD-induced hepatic fibrosis in mice.Casp11+/+ (WT) or Casp 11–/– mice were treated with MCD for 8 weeks to induce NASH. The mRNA level of (A) Tgfb1, (B) α-Sma, and (C) Col1a1 was determined by reverse-transcription quantitative PCR. n = 5 for 2 control groups, n = 8 for 2 MCD groups. ∗∗P < .01.
