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. 2021 Apr 21;12(2):653–664. doi: 10.1016/j.jcmgh.2021.04.009

Figure 4.

Figure 4

Deletion of caspase-11–inhibited MCD-induced inflammation in liver.Casp11+/+ (WT) or Casp 11–/– mice were treated with MCD for 8 weeks to induce NASH. (A, B) The infiltration of immune cells (CD45+) in liver was determined by fluorescence-activated cell sorting, and (C) the mRNA level of F4/80 was determined by reverse-transcription quantitative PCR. And the protein level of (D) TNF-α, (E) IL-1β, and (F) CCL2 was detected by enzyme-linked immunosorbent assay. n = 5 for 2 control groups, n = 8 for 2 MCD groups. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, ∗∗∗∗P < .0001. ns, no significance.