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. 2021 Jun 23;8:691795. doi: 10.3389/fmolb.2021.691795

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Copyright © 2021 Wang, Zhao, Fu, Xu and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cisplatin resistance mechanism. (1) Reduced intracellular accumulation of cisplatin. (2) Increased sequestration of cisplatin by GSH and other cytoplasmic scavengers with nucleophilic properties. (3) Enhanced DNA damage repair ability. (4) Defects in apoptotic signal transduction pathways. The figure was drawn in Adobe Illustrator.