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. 2021 Jun 23;13:670463. doi: 10.3389/fnagi.2021.670463

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Copyright © 2021 Cao, Nie, Zhang, Chen, Wang, Liu, Mo, Du, Hu, Tian, Wei and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Voxel-based morphometry showing gray matter loss in the cerebellar subregions for patients with White matter hyperintensities (WMHs) in comparison with controls. Areas of significant gray matter loss (red) included the cerebellar subregions right-sided lobule VI [voxel size: 2,106; peak MNI coordinates: x = 22.5, y = –63, and z = –15; Gaussian random field (GRF) for voxel levels at P < 0.001 and cluster at P < 0.05] and left-sided lobule VI (voxel size: 703; peak MNI coordinates: x = –22.5, y = –54, and z = –15; GRF for voxel levels at P < 0.001 and cluster at P < 0.05), for patients with WMHs vs. control subjects.