Fig. 5.

MMP-2-responsive nanoparticles for synergistic antitumor effect of anti-angiogenesis and chemotherapy. (A) Schematic illustration of the co-assembly and disassembly of nanoparticles subject to MMP-2 stimuli. (B) Accumulative release of drug from nanoparticles in different media. (C) Tumor sizes with time after different treatments. (D) In vivo biodistribution of tumor-bearing mice after administration of Cy5.5 loaded nanopraticles and free Cy5.5. Adapted with permission from [64]. Copyright 2016, American Chemical Society.