Table 3.
Main clinical laboratory profiles of critical patients with COVID-19.
| Laboratory tests | On admission | Day2-3 after admission | Last test before achievement of clinical outcome | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total (N=48) | Deceased (N=18) | Survivial (N=30) | P value | Total (N=48) | Deceased (N=18) | Survivial (N=30) | P value | Total (N=48) | Deceased (N=18) | Survivial (N=30) | P value | |
| Glucose (mmol/L) | 6.5(5.4, 9.1) | 7.24(5.41,11.39) | 6.49(4.72,8.69) | 0.688 | 6.62 (4.77, 9.19) | 7.52(6.05,9.02) | 6.33(4.65,9.20) | 0.546 | 7.07 (5.31, 11.53) | 7.96(6.02,15.54) | 6.89(5.07, 10.63) | 0.180 |
| Cre (umol/L) | 73 (55, 110) | 80.70(60.50,121.25) | 68.40(51.10,99.10) | 0.289 | 75.05 (51.30,144.20) | 81.50(57.90,127.70) | 73.4(50.65,157.75) | 0.618 | 74.4 (49.88,159.83) | 118.10(55.30,219.20) | 73.20(47.75,125.30) | 0.363 |
| UA (umol/L) | 230 (164, 332) | 225(153.50,335.50) | 235.00(161.00,333.00) | 0.664 | 231 (150, 313) | 168(127.75,264.25) | 242.00(191.50,331.00) | 0.130 | 160 (124, 308) | 151(90,354.50) | 163.00(124.50,300.50) | 0.559 |
| Cys (mg/L) | 1.21 (1.03,1.85) | 1.28 (1.09,2.10) | 1.18 (0.93,1.71) | 0.339 | 1.15 (1.00, 2.14) | 1.22 (1.07,1.95) | 1.14 (0.95,2.16) | 0.511 | 1.30 (0.97, 2.51) | 1.62 (1.07,2.69) | 1.05 (0.89,1.91) | 0.201 |
| PCT (ng/mL) | 0.22 (0.10,1.21) | 1.10 (0.19,1.78) | 0.13 (0.08,0.30) | 0.033 | 0.21 (0.09, 0.62) | 0.39 (0.17,0.79) | 0.21 (0.088,0.57) | 0.473 | 0.30 (0.11,1.30) | 1.03 (0.61,4.79) | 0.14 (0.08,1.08) | 0.017 |
| ALT (IU/L) | 30 (18, 48) | 35 (24.40,61.05) | 25.00 (17.00,48.50) | 0.162 | 37.50 (17.75, 65.50) | 25.50 (17.75,67.25) | 39 (17.25,64.50) | 0.677 | 28.00 (12.00, 56.50) | 35 (4.75,228.00) | 25.00 (26.00,58.75) | 0.681 |
| AST (IU/L) | 38 (23, 58) | 43 (38,67) | 30.00 (21.00,49.50) | 0.042 | 40.00 (26.75, 59.25) | 38.50 (31.50,82.00) | 40.5 (26.00,58.75) | 0.532 | 33.00 (21.50, 60.00) | 58 (29.75,403.75) | 24.00 (20.00,35.00) | 0.024 |
| TP (g/L) | 58 (53, 63) | 58.10 (50.85,62.95) | 58.30 (53.65,63.50) | 0.724 | 57.15 (50.10, 63.05) | 54.10 (46.73,59.23) | 59.30 (50.40,64.30) | 0.151 | 54.00 (50.40, 61.20) | 51.50 (45.78,59.83) | 54.90 (50.50,65.20) | 0.096 |
| ALB (g/L) | 30 (27, 32) | 28.55 (24.08,32.35) | 30.20 (28.55,32.40) | 0.125 | 28.7 (27.15, 31.00) | 28 (23.55,30.18) | 28.90 (27.43,32.38) | 0.112 | 29.90 (27.60, 33.40) | 29.50 (23.40,31.58) | 30.80 (28.10,35.00) | 0.092 |
| TBIL (umol/L) | 11.6 (7.4, 17.8) | 14.20 (7.23,23.85) | 10.75 (7.25,15.95) | 0.237 | 11.40 (7.15, 17.50) | 11.75 (7.68,27.38) | 11.40 (6.65,17.00) | 0.545 | 10.10 (7.10, 20.15) | 24.50 (13.33,46.45) | 8.20 (6.90,14.90) | 0.000 |
| DBIL (umol/L) | 5.8 (4.0, 9.9) | 8.20 (4.78,15.35) | 5.10 (3.38,7.40) | 0.053 | 4.95 (3.68, 10.30) | 7.15 (4.35,16.95) | 4.65 (3.10,9.95) | 0.219 | 89.50 (61.00, 120.00) | 19.80 (8.30,39.25) | 4.50 (2.80,10.00) | 0.001 |
| ALP (IU/L) | 85.5 (60.5, 118) | 97 (69.75,142.15) | 82.50 (57.50,112.75) | 0.265 | 77.00 (60.50, 103.0) | 64 (59,84.50) | 83.00 (62.00, 112.0) | 0.273 | 89.50 (61.00,120.00) | 77.00 (56.25,116.25) | 92.00 (66.75,123.50) | 0.528 |
| GGT (IU/L) | 46 (29,76) | 55.95 (25,117.75) | 39.00 (29.00,62.50) | 0.283 | 46.00 (29.00, 69.00) | 36.50 (14.00,80.50) | 47.00 (30.00,66.00) | 0.531 | 42.00 (30.50, 58.25) | 41.00 (18.75,62.75) | 43.50 (32.75,60.50) | 0.655 |
| K+ (mmol/L) | 4.4 (3.8, 4.8) | 4.48 (3.85,4.82) | 4.40 (3.75,4.77) | 0.753 | 4.26 (3.88, 4.67) | 4.11 (3.85,4.38) | 4.39 (3.80,5.16) | 0.243 | 4.44 (4.05,4.97) | 5.07 (4.44,5.50) | 4.27 (3.86,4.68) | 0.017 |
| Na+ (mmol/L) | 140 (137.3, 145.7) | 145.75 (139.63,148.10) | 139.30 (136.90,140.90) | 0.003 | 140.4 (137.6,144.08) | 143.65 (134.73,151.33) | 140.05 (137.60,142.83) | 0.267 | 140.85 (136.93,147.9) | 141.85 (137.50,153.10) | 140.85 (136.33,145.65) | 0.408 |
| C-Ca2+ (mmol/L) | 2.17 (2.10, 2.25) | 2.17 (2.10,2.24) | 2.16 (2.10,2.28) | 0.633 | 2.19 (2.13,2.26) | 2.22 (2.14,2.26) | 2.18 (2.06,2.28) | 0.610 | 2.23 (2.12,2.31) | 2.22 (2.12,2.33) | 2.24 (2.06,2.28) | 1.000 |
| P (mmol/L) | 0.92 (0.79, 1.19) | 0.98 (0.79,1.22) | 0.85 (0.78,1.17) | 0.364 | 0.83 (0.69,1.06) | 0.69 (0.53,0.92) | 0.86 (0.77,1.14) | 0.058 | 0.93 (0.71,1.25) | 0.89 (0.58,1.68) | 0.95 (0.75,1.22) | 0.715 |
| Mg2+ (mmol/L) | 0.84 (0.77, 0.95) | 0.91 (0.81,1.04) | 0.84 (0.77,0.89) | 0.060 | 0.82 (0.78,0.93) | 0.86 (0.75,0.96) | 0.82 (0.78,0.92) | 0.705 | 0.83 (0.76,0.90) | 0.84 (0.77,0.97) | 0.82 (0.76,0.87) | 0.514 |
| CK (IU/L) | 96 (42, 429) | 186 (59.05,1266.25) | 78.00 (38.00,192.00) | 0.191 | 103 (40.50,326.75) | 323.00 (90.50,458.50) | 75.00 (33.00,166.00) | 0.034 | 72 (32.5,143.75) | 159.00 (111.50,856.50) | 52.00 (29.00,87.00) | 0.006 |
| LDH (IU/L) | 407 (283, 528) | 447.90 (366.00,644.25) | 376.00 (256.00,477.00) | 0.128 | 401.0 (277.5,545.5) | 449.00 (372.5,593.00) | 380.00 (224.00,544.00) | 0.187 | 324.50 (257.00,602.75) | 645.00 (432.00,1279.00) | 276.00 (229.00,369.00) | 0.002 |
| HBDH (IU/L) | 346 (214, 455) | 407.50 (313.50,576.00) | 305.00 (192.00,364.00) | 0.017 | 312.5 (216.8,429.75) | 372.00 (280.00,439.50) | 290.00 (182.00,429.00) | 0.285 | 255.00 (189.25,467.75) | 395.00 (322.00,647.00) | 216.00 (176.00,278.00) | 0.004 |
| TC (mmol/L) | 3.07 (2.10, 3.67) | 2.56 (2.04,3.25) | 3.31 (2.55,4.01) | 0.029 | 2.82 (2.37,3.53) | 2.32 (1.47,2.62) | 3.13 (2.67,3.88) | 0.002 | 2.18 (1.68,2.89) | 1.69 (1.34,2.22) | 2.29 (1.76,3.77) | 0.037 |
| TG (mmol/L) | 0.85 (0.56, 1.32) | 0.93 (0.64,1.41) | 0.81 (0.43,1.17) | 0.257 | 0.94 (0.58,1.18) | 0.71 (0.20,1.21) | 0.96 (0.74,1.13) | 0.377 | 0.91 (0.61,1.30) | 0.97 (0.80,1.40) | 0.83 (0.57,1.27) | 0.248 |
| HDL (mmol/L) | 0.81 (0.67, 1.03) | 0.75 (0.64,0.88) | 0.90 (0.69,1.29) | 0.017 | 0.78 (0.68,0.96) | 0.76 (0.63,0.87) | 0.83 (0.69,1.03) | 0.238 | 0.61 (0.43,0.88) | 0.49 (0.27,0.62) | 0.69 (0.46,0.93) | 0.039 |
| LDL (mmol/L) | 1.79 (1.31, 2.18) | 1.69 (1.15,2.08) | 1.92 (1.46,2.55) | 0.136 | 1.74 (1.48,2.08) | 1.46 (1.24,1.98) | 1.84 (1.64,2.15) | 0.054 | 1.33 (1.00,1.96) | 1.06 (0.71,1.32) | 1.57 (1.13,2.26) | 0.015 |
| APOA (g/L) | 0.81 (0.68, 1.05) | 0.75 (0.63,0.86) | 0.87 (0.71,1.23) | 0.033 | 0.79 (0.69,1.01) | 0.73 (0.64,0.82) | 0.85 (0.69,1.08) | 0.144 | 0.60 (0.43,0.89) | 0.43 (0.28,0.56) | 0.76 (0.56,1.00) | 0.002 |
| APOB (g/L) | 0.81 (0.62, 1.05) | 0.83 (0.64,1.02) | 0.81 (0.59,1.10) | 0.776 | 0.75 (0.68,0.97) | 0.74 (0.63,0.97) | 0.79 (0.68,0.97) | 0.479 | 0.62 (0.50,0.79) | 0.50 (0.40,0.67) | 0.65 (0.52,0.89) | 0.094 |
Cre, creatinine; UA, uric acid; Cys, Cystatin; PCT, Procalcitonin; ALT, Alanine aminotransferase; AST, Glutamic oxaloacetylase; TP, Total protein; ALB, Albumin; TBIL, total bilirubin; DBIL, Direct bilirubin; ALP, alkaline phosphatase; GGT, r-glutamyltranspeptidase; C-Ca2+ corrected calcium; LDH, lactate dehydrogenase; HBDH, α-Hydroxybutyrate dehydrogenase; TC, total cholesterol; TG, triglyceride; HDL, high density lipoprotein; LDL, low density lipoprotein; APOA, apolipoprotein A; APOB, apolipoprotein B.Data expressed as median (interquartile range [IQR]).