Table 1.
Characteristics of SNPs for exposures from GWAS.
| Exposure | Gene | SNP | Chromosome: Position | EA | Association with exposure | |
|---|---|---|---|---|---|---|
| β (SE) | P value | |||||
| E2 | CYP19A1 | rs727479 | 15:51534547 | A | 1.39 (0.12) | 8.2×10-30 |
| E2 | CYP19A1 | rs16964258 | 15:51605408 | G | 2.13 (0.25) | 8.2×10-15 |
| E2 | FAM9B | rs5934505 | X:8913826 | C | 0.67 (0.12) | 3.4×10-8 |
| E2 | MIR | rs5951794 | X:146432188 | G | 0.68 (0.11) | 3.1×10-10 |
| DHEAS | BCL2L11 | rs6738028 | 2:111949327 | G | -0.04 (0.01) | 1.72×10-8 |
| DHEAS | ARPC1A | rs740160 | 7:98957880 | T | 0.15 (0.02) | 1.56×10-16 |
| DHEAS | TRIM4 | rs17277546 | 7:99489571 | A | -0.11 (0.02) | 4.50×10-11 |
| DHEAS | HHEX | rs2497306 | 10:94485211 | C | -0.04 (0.01) | 4.64×10-9 |
| DHEAS | CYP2C9 | rs2185570 | 10:96751270 | C | -0.06 (0.01) | 2.29×10-8 |
| DHEAS | BMF | rs7181230 | 15:40360741 | G | 0.05 (0.01) | 5.44×10-11 |
| DHEAS | SULT2A1 | rs2637125 | 19:48401893 | A | -0.09 (0.01) | 2.61×10-19 |
| T | JMJD1C | rs10822186 | 10:65350383 | A | -0.06 (0.01) | 1.20×10-8 |
| T | SHBG | rs4239258 | 17:7397043 | A | -0.16 (0.03) | 4.47×10-8 |
| T | SHBG | rs34790908 | 17:7451110 | T | 0.07 (0.01) | 1.66×10-9 |
| T | SHBG | rs727428 | 17:7537792 | T | -0.07 (0.01) | 1.26×10-12 |
| DHT | SHBG | rs4151121 | 17:7342294 | G | 0.10 (0.02) | 7.96×10-10 |
| DHT | SHBG | rs4265880 | 17:7396267 | T | -0.24 (0.04) | 1.89×10-8 |
| DHT | SHBG | rs4227 | 17:7491177 | G | 0.09 (0.02) | 3.68×10-8 |
Gene, nearest gene to the SNP; EA, effect allele; β, per allele effect on the exposure; SE, standard error; P value, p-value for the genetic association.