Figure 3.

Inhibition of xCT upregulated the expression of PD-L1 in melanoma cells

(A) Cell lysates and mRNA were extracted from SAS-treated melanoma cells as indicated, and immunoblotting (upper panels) and quantitative real-time PCR (lower panels) were then performed. Data are presented as the mean ± SD. (B) Cell lysates and mRNA were extracted from lentivirus-infected melanoma cells as indicated, and immunoblotting (upper panels) and quantitative real-time PCR (lower panels) were then performed. Data from multiple experiments are expressed as the mean (n = 3) ± SD. Asterisks indicate significant differences: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001.