Table 3.
Allele and genotype frequencies in patients with SSc and controls.
| Gene | SNP | Allele Frequency (%) | Genotype Frequency (%) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Allele | Case/control (%) | P | OR (95%CI) | Genotype | Case/control (%) | P | χ2 | ||
| GTF2I | rs117026326 | T | 166/192 (24.6/13.9) | 6.97E-10 | 2.22 (1.72-2.86) | TT | 23/10 (6.8/1.4) | 6.25E-09 | 37.78 |
| C | 510/1190 (75.4/86.1) | TC | 120/172 (35.5/24.9) | ||||||
| CC | 195/509 (57.7/73.7) | ||||||||
| rs73366469 | C | 181/228 (26.8/16.6) | 1.33E-08 | 2.02 (1.58-2.57) | CC | 26/14 (7.7/2.0) | 1.67E-08 | 35.82 | |
| T | 495/1148 (73.2/83.4) | TC | 129/200 (38.2/29.1) | ||||||
| TT | 183/474 (54.1/68.9) | ||||||||
| NFKB1 | rs1599961 | A | 308/560 (40.8/45.3) | 0.086 | 1.19 (0.97-1.46) | AA | 63/124 (18.5/18.1) | 0.014 | 8.51 |
| G | 372/814 (59.2/54.7) | AG | 182/312 (53.5/45.4) | ||||||
| GG | 95/251 (28.0/36.5) | ||||||||
| TYK2 | rs2304256 | A | 296/626 (45.4/43.5) | 0.592 | 0.95 (0.77-1.56) | AA | 67/140 (19.7/20.3) | 0.599 | 1.03 |
| C | 384/754 (54.6/56.5) | CA | 162/346 (47.7/50.1) | ||||||
| CC | 111/204 (32.6/29.6) | ||||||||
SSc, systemic sclerosis.