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(A) Schematic of the binding interaction between SARS-CoV-2 and the lung epithelium, showing bound and unbound ACE2 receptors and spike proteins. The magenta box shows an individual spike to ACE2 receptor interaction, which is expanded in (B). (B) Selection of the best-predicted mutations from Fig. 3 b (in (4)) at residues 455, 493, 494, and 501 of the spike protein. To see this figure in color, go online.
