Table 3. Significantly enriched hallmarks in the TCGA cohort by GSEA.

Name	Size	NES	NOM p-val	FDR q-val	Signal score
HALLMARK_BILE_ACID_METABOLISM	112	2.35	0.00E+00	7.00E-04	Low
HALLMARK_XENOBIOTIC_METABOLISM	200	2.24	0.00E+00	7.00E-04	Low
HALLMARK_COAGULATION	138	2.05	0.00E+00	7.19E-03	Low
HALLMARK_FATTY_ACID_METABOLISM	158	2.03	1.84E-03	6.52E-03	Low
HALLMARK_PEROXISOME	103	1.94	1.89E-03	1.45E-02	Low
HALLMARK_ADIPOGENESIS	200	1.93	3.74E-03	1.24E-02	Low
HALLMARK_HEME_METABOLISM	197	1.62	8.13E-03	1.06E-01	Low
HALLMARK_G2M_CHECKPOINT	197	−2.27	0.00E+00	4.52E-03	High
HALLMARK_E2F_TARGETS	200	−2.14	0.00E+00	5.00E-03	High
HALLMARK_MYC_TARGETS_V1	199	−2.09	2.04E-03	6.13E-03	High
HALLMARK_MTORC1_SIGNALING	200	−1.94	6.21E-03	2.81E-02	High
HALLMARK_MYC_TARGETS_V2	58	−1.87	2.08E-02	4.07E-02	High
HALLMARK_DNA_REPAIR	149	−1.83	9.94E-03	4.81E-02	High
HALLMARK_MITOTIC_SPINDLE	198	−1.69	3.41E-02	1.09E-01	High
HALLMARK_UNFOLDED_PROTEIN_RESPONSE	112	−1.68	2.29E-02	1.05E-01	High
HALLMARK_UV_RESPONSE_UP	158	−1.62	2.52E-03	1.32E-01	High
HALLMARK_SPERMATOGENESIS	133	−1.54	2.91E-02	1.79E-01	High

TGCA, The Cancer Genome Atlas; GESA, Gene Set Enrichment Analysis; NES, Normalized Enrichment Score; NOM p-val, Nominal p value.