Table 2. Clinicopathological factors, R-NLR score, and survival univariate and multivariate analyses (n=151).

Factors	OS								DFS
	Univariate				Multivariate				Univariate				Multivariate
	HR	95% CI	P		HR	95% CI	P		HR	95% CI	P		HR	95% CI	P
Gender (male vs. female)	0.784	0.505–1.218	0.279		–	–	–		0.901	0.606–1.339	0.606		–	–	–
Age (<60 vs. ≥60 years)	1.173	0.762–1.807	0.469		–	–	–		1.107	0.756–1.622	0.602		–	–	–
Tumor size (<6 vs. ≥6 cm)	1.815	1.158–2.846	0.009		1.541	0.957–2.479	0.075		1.588	1.059–2.382	0.025		1.343	0.875–2.061	0.178
Tumor location	1.126	0.874–1.451	0.36		–	–	–		1.124	0.900–1.403	0.304		–	–	–
Differentiation	1.843	1.268–2.681	0.001		1.439	0.992–2.087	0.055		1.85	1.136–2.600	<0.001		1.643	1.163–2.322	0.005
T stage (T3 vs. T4)	2.797	1.443–5.422	0.002		2.228	1.126–4.409	0.021		2.869	1.631–5.046	<0.001		2.669	1.448–4.918	0.002
Lymph node status (negative vs. positive)	3.159	1.745–5.721	<0.001		1.153	0.601–2.422	0.135		2.992	1.834–4.882	<0.001		1.603	0.728–3.866	0.205
TNM stage (II vs. III)	3.714	2.049–6.729	<0.001		2.486	1.640–3.666	0.039		3.277	2.025–5.302	<0.001		1.622	1.137–2.502	0.092
Neurological invasion (yes vs. no)	1.197	0.759–1.887	0.439		–	–	–		1.289	0.864–1.921	0.213		–	–	–
Vascular invasion (yes vs. no)	2.504	1.589–3.944	<0.001		1.894	1.188–3.021	0.012		2.283	1.510–3.450	<0.001		1.678	1.096–2.568	0.017
Preoperative NLR level	1.357	0.882–2.088	0.164		–	–	–		1.84	1.254–2.700	0.002		1.939	1.294–2.906	0.001
Preoperative RDW-cv level	1.777	1.140–2.768	0.114		–	–	–		1.726	1.162–2.564	0.007		1.537	1.015–2.327	0.042
R-NLR score	1.417	1.072–1.872	0.011		1.527	1.123–2.077	0.007		1.569	1.233–1.998	<0.001		1.939	1.294–2.906	0.001

R-NLR, red blood cell distribution width-neutrophil to lymphocyte ratio; OS, overall survival; DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; RDW-cv, red blood cell distribution width-variation coefficient.