Table 3. Study characteristics of lncRNA and circRNA found in urine for diagnosis of UBC, with their sensitivity and specificity.
Year | RNA | Gene | Analytic approach | Sample | Sensitivity | Specificity | Notes | Ref |
---|---|---|---|---|---|---|---|---|
2014 | lncRNA | UCA-1 | RT-PCR | Urine, T24 cell line | 79.5 | 79.7 | High grade disease (G2-G3) sensitivity =84.09% | (226) |
2015 | lncRNA | UCA-1 | RT-PCR | Urine | 70 | 70.7 | Limited role in follow-up recurrence tumours | (227) |
2015 | lncRNA | UCA1 | Hybridization assay; Nanoassay RT-qPCR | Urine | 92.1 | 93.3 | – | (228) |
2017 | lncRNA | H19 | RT-PCR | Urine | 90.5 | 74.1 | – | (229) |
2018 | lncRNA (cell free) | uc004cox.4 GAS5 | microarray, RT-qPCR | Urine | 84.5 | 78.2 | – | (230) |
2020 | circRNA | Hsa_circ_0137439 | microarray, RT-qPCR | Urine | 87.93 | 80.06 | Independent prognostic predicator of RFS and OS; Knockdown contributed to inhibition of cell proliferation and migration via hsa_circ_0137439/miR-142-5p/ MTDH axis |
(231) |
2020 | lncRNA | UCA1-201, HOTAIR, HYMA1, MALAT1 | RT-qPCR | Urine | 95.7 | 94.3 | – | (232) |