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. 2021 Jun;10(6):2787–2808. doi: 10.21037/tau-20-1327

Table 3. Study characteristics of lncRNA and circRNA found in urine for diagnosis of UBC, with their sensitivity and specificity.

Year RNA Gene Analytic approach Sample Sensitivity Specificity Notes Ref
2014 lncRNA UCA-1 RT-PCR Urine, T24 cell line 79.5 79.7 High grade disease (G2-G3) sensitivity =84.09% (226)
2015 lncRNA UCA-1 RT-PCR Urine 70 70.7 Limited role in follow-up recurrence tumours (227)
2015 lncRNA UCA1 Hybridization assay; Nanoassay RT-qPCR Urine 92.1 93.3 (228)
2017 lncRNA H19 RT-PCR Urine 90.5 74.1 (229)
2018 lncRNA (cell free) uc004cox.4 GAS5 microarray, RT-qPCR Urine 84.5 78.2 (230)
2020 circRNA Hsa_circ_0137439 microarray, RT-qPCR Urine 87.93 80.06 Independent prognostic predicator of RFS and OS; Knockdown contributed to inhibition of cell proliferation and migration via hsa_circ_0137439/miR-142-5p/
MTDH axis
(231)
2020 lncRNA UCA1-201, HOTAIR, HYMA1, MALAT1 RT-qPCR Urine 95.7 94.3 (232)