TABLE 2.
Age‐ and sex‐adjusted estimated change in brain MRI markers per standard deviation decrease in average mRNFL, mGCIPL, mGCC and total macular thickness
| mRNFL thickness | mGCIPL thickness | mGCC thickness | Total macular thickness | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | 95% CI | p value | β | 95% CI | p value | β | 95% CI | p value | β | 95% CI | p value | |
| Total brain normalised | −0.04 | (−0.07, −0.002) | 0.04 | −0.08 | (−0.12, −0.05) | <0.001 | −0.08 | (−0.12, −0.05) | <0.001 | −0.08 | (−0.12, −0.05) | <0.001 |
| Grey matter normalised | ||||||||||||
| Total normalised | −0.04 | (−0.07, −0.005) | 0.022 | −0.05 | (−0.08, −0.01) | 0.007 | −0.06 | (−0.09, −0.02) | 0.001 | −0.06 | (−0.09, −0.03) | <0.001 |
| Frontal pole | −0.02 | (−0.06, 0.01) | 0.19 | −0.04 | (−0.07, 0.0008) | 0.06 | −0.04 | (−0.08, −0.004) | 0.030 | −0.04 | (−0.08, −0.003) | 0.034 |
| Temporal pole | 0.002 | (−0.04, 0.04) | 0.92 | −0.03 | (−0.07, 0.01) | 0.21 | −0.02 | (−0.06, 0.02) | 0.39 | −0.04 | (−0.08, 0.006) | 0.09 |
| Occipital pole | −0.02 | (−0.06, 0.02) | 0.42 | −0.06 | (−0.10, −0.02) | 0.004 | −0.06 | (−0.10, −0.01) | 0.009 | −0.05 | (−0.09, −0.009) | 0.017 |
| White matter volume | ||||||||||||
| Total normalised | −0.02 | (−0.06, 0.02) | 0.28 | −0.09 | (−0.13, −0.05) | <0.001 | −0.08 | (−0.12, −0.04) | <0.001 | −0.07 | (−0.11, −0.03) | 0.001 |
| Hippocampal normalised | −0.04 | (−0.08, −0.004) | 0.030 | −0.03 | (−0.07, 0.005) | 0.09 | −0.05 | (−0.09, −0.01) | 0.012 | −0.05 | (−0.09, −0.01) | 0.008 |
Values represent standardised mean difference in z scores of total brain, grey or white matter, and hippocampal normalised per SD decrease in retinal sublayer thickness. Values are adjusted for age, age squared and sex. Bold values denote statistical significance at the p < 0.05 level.
Abbreviations: mGCC, macular ganglion cell complex; mGCIPL, macular ganglion cell‐inner plexiform layer; mRNFL, macular retinal nerve fibre layer.