TABLE 3.

Multivariable adjusted estimated change in brain MRI markers per standard deviation decrease in average mRNFL, mGCIPL, mGCC and total macular thickness

	mRNFL thickness			mGCIPL thickness			mGCC thickness			Total macular thickness
	β	95% CI	p value	β	95% CI	p value	β	95% CI	p value	β	95% CI	p value
Total brain normalised	−0.03	(−0.07, 0.004)	0.08	−0.08	(−0.12, −0.05)	<0.001	−0.08	(−0.12, −0.04)	<0.001	−0.08	(−0.11, −0.04)	<0.001
Grey matter normalised
Total normalised	−0.03	(−0.06, 0.002)	0.06	−0.04	(−0.08, −0.01)	0.009	−0.05	(−0.08, −0.02)	0.003	−0.06	(−0.09, −0.02)	0.001
Frontal pole	−0.02	(−0.06, 0.01)	0.24	−0.04	(−0.07, 0.001)	0.06	−0.04	(−0.08, −0.002)	0.038	−0.04	(−0.08, 0.0001)	0.05
Temporal pole	0.005	(−0.04, 0.05)	0.80	−0.02	(−0.07, 0.02)	0.23	−0.02	(−0.06, 0.03)	0.46	−0.03	(−0.07, 0.007)	0.11
Occipital pole	−0.02	(−0.06, 0.02)	0.37	−0.06	(−0.10, −0.02)	0.003	−0.06	(−0.10, −0.02)	0.006	−0.05	(−0.09, −0.008)	0.020
White matter normalised
Total normalised	−0.02	(−0.06, 0.02)	0.32	−0.09	(−0.13, −0.05)	<0.001	−0.08	(−0.12, −0.04)	<0.001	−0.07	(−0.11, −0.03)	0.001
Hippocampal normalised	−0.04	(−0.08, 0.0002)	0.05	−0.03	(−0.07, 0.006)	0.09	−0.05	(−0.09, −0.008)	0.018	−0.05	(−0.09, −0.01)	0.010

Values represent standardised mean difference in z scores of total brain, grey or white matter and hippocampal normalised per SD decrease in retinal sublayer thickness. Values are adjusted for age, age squared, sex, race, education, body mass index, mean arterial blood pressure and smoking. Bold values denote statistical significance at the p < 0.05 level.

Abbreviations: mGCC, macular ganglion cell complex; mGCIPL, macular ganglion cell‐inner plexiform layer; mRNFL, macular retinal nerve fibre layer.