A–D: Molecular immunohistochemical staining for cytokeratin 5 (CK5) (A), tumor protein P63 (p63) (B), cyclin-dependent kinase inhibitor 2A (p16) (C), and marker of proliferation Ki-67 (D). Arrow indicates basal layer; dashed circle, nests of squamous cell carcinoma. Scale bar = 20 μm. SSE, stratified squamous epithelium, LP, lamina propria.