Figure 5.

Uterine histologic analysis in Pgr^+/+ and Arid1a^flox/flox; Kras^{Lox-Stop-Lox-G12D/+}; Pgr^Cre/+ (AKP) mice with and without 17-β-estradiol (E2) treatment. A: 16-week–old intact Pgr^+/+ and AKP mouse uteri are shown for comparison. B: AKP intact uteri have endometrial hyperplasia. Ovariectomized AKP sham mice are similar in histologic findings to ovariectomized Pgr^+/+ sham mice. C: Ovariectomized Pgr^+/+-E2 mice had enlarge dilated uteri without evidence of endometrial hyperplasia or atypia. Ovariectomized AKP-E2 mice had squamous metaplasia of the endometrium (black arrow). Hematoxylin and eosin staining. Scale bar = 50 μm. LE, luminal epithelium.