Table 3.
Tumor response according to treatment line and ICI regimen
| Objective response by treatment line | |||||
|---|---|---|---|---|---|
| Response | Any line N = 94 (100%) n (%) |
ICI in first line n = 9 (10%) n (%) |
ICI in second line n = 42 (45%) n (%) |
ICI in third line n = 20 (21%) n (%) |
ICI in fourth line and beyond n = 23 (24%) n (%) |
| ORR (CR + PR) | 37 (39.4) | 3 (33) | 17 (40.4) | 7 (35) | 10 (43.5) |
| DCR (CR + PR + SD) | 61 (65) | ||||
| CR | 7 (7.4) | 0 (0) | 2 (4.8) | 2 (10%) | 3 (13) |
| PR | 30 (32) | 3 (33) | 15 (35.7) | 5 (25%) | 7 (30.4) |
| SD | 24 (25.5) | 4 (44) | 11 (26.2) | 6 (30%) | 3 (13) |
| PD | 33 (35) | 2 (22) | 14 (33.3) | 7 (35%) | 10 (43.5) |
| Objective response rates according to ICI regimen | |||
|---|---|---|---|
| Response | ICI monotherapy, n (%) 55 (59) |
Dual ICI therapy, n (%) 19 (20) |
ICI + TKI, n (%) 20 (21) |
| ORR (CR + PR) | 20 (36.3) | 8 (42) | 9 (45) |
| DCR (CR + PR + SD) | 31 (56.4) | 15 (79) | 15 (75) |
| CR | 4 (7.3) | 1 (5.2) | 2 (10) |
| PR | 16 (29) | 7 (36.8) | 7(35) |
| SD | 11 (20) | 7 (36.8) | 6 (30) |
| PD | 24 (43.6) | 4 (21) | 5 (25) |
CR, complete response; DCR, disease control rate; ORR, objective response rate; PD, disease progression, PR, partial response; SD, stable disease.