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. 2021 May 29;28(3):2065–2078. doi: 10.3390/curroncol28030191

Figure 4.

Figure 4

Heatmap graphics showing the rationale (A) and eligibility criteria (B) for neoadjuvant therapy for T4 colon cancer. Each box in the grid represents the number of studies (color coded per the legend) that use the rationale (A) or eligibility criteria (B) listed on the y-axis, corresponding to the neoadjuvant therapy listed on the x-axis. (Categories are not mutually exclusive). NAT, neoadjuvant therapy; CRC, colorectal cancer; R0, microscopically negative margins; AC, adjuvant chemotherapy; CT, computed tomography.