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. 2021 May 31;6(2):48. doi: 10.3390/jfmk6020048

Figure 1.

Figure 1

Continuous progressive (CP) aerobic exercise (AE) promotes physical performance and affects muscle fiber expression. (A) Schematic representation of CP exercise: CP program was carried out three times a week for a total time of 12 weeks. The training schedule is reported: 120” at 10 RPM, 120” at 12 RPM, 120” at 14 RPM, 120” at 16 RPM, 90” at 18 RPM, 90” at 20 RPM, 90” at 22 RPM, 90” at 24 RPM, 90” at 26 RPM, 60” at 28 RPM, 60” at 30 RPM, and 30” at 32 RPM. (B) Timeline of the training program. (C) Body weight of sedentary and trained mice at the end of exercise. (D) Histogram reporting the strength evaluated at the end of exercise, through a test using a force transducer as reported in materials and methods. (E) Histogram reporting resistance as number of falls in trained and sedentary mice. Resistance was evaluated by a test on the RotaRod at constant speed of 10 RPM considering the falls number/time (CP: 1st week 12.3 ± 9.1, 6th week 3.2 ± 3.6, and 12th week 2.0 ± 2.8). * p < 0.05. Error bars represent SD. (F–I) Relative expression of MyHC isoforms of quadriceps muscles from sedentary (S) and trained (T) mice. RT-qPCR analysis shows the expression levels (normalized to CyPA) of MyHC-I, MyHC-IIa, MyHC-IIb, and MyHC-IIx, in S e T mice. Statistical analysis was performed by unpaired Student’s t-test and two-way ANOVA (* p < 0.05; ** p < 0.01).